Estrogen worsens incipient hypertriglyceridemic glomerular injury in the obese Zucker rat
نویسندگان
چکیده
منابع مشابه
Fosinopril ameliorates exogenous cholesterol-induced incipient glomerular lesions in obese Zucker rats. Effects on eicosanoid secretion.
BACKGROUND To date, the role of dietary cholesterol as a risk factor for some diabetic nephrophathy, such as mesangial expansion and glomerular lesions, is unknown. Controversy also exists regarding the effects of prostaglandin-induced changes in glomerular haemodynamics on the appearance of glomerulosclerosis. METHODS We have used obese Zucker rats (OZRs) as a model of early nephrophathy to ...
متن کاملEarly influx of glomerular macrophages precedes glomerulosclerosis in the obese Zucker rat model.
Because hyperlipidemia and macrophage influx appear to play a key role in the genesis of renal glomerulosclerosis, this study examined the temporal relationship between hyperlipidemia (triglycerides and cholesterol), mononuclear cell influx, changes in glomerular structure, and expansion of the extracellular matrices in obese Zucker rats, which rapidly develop hyperlipidemia and spontaneous glo...
متن کاملMechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat.
Inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase have been approved for treatment of hypercholesterolemia in humans. This class of therapeutic agents, in addition to lowering plasma cholesterol, reduces plasma triglyceride levels. We have investigated the mechanism of triglyceride-lowering effect of lovastatin in the hypertriglyceridemic state by using a rodent model of ...
متن کاملDPP4 inhibition attenuates filtration barrier injury and oxidant stress in the Zucker obese rat
OBJECTIVE Obesity-related glomerulopathy is characterized initially by glomerular hyperfiltration with hypertrophy and then development of proteinuria. Putative mechanisms include endothelial dysfunction and filtration barrier injury due to oxidant stress and immune activation. There has been recent interest in targeting dipeptidyl peptidase 4 (DPP4) enzyme due to increasing role in non-enzymat...
متن کاملResponse of the aorta of the obese Zucker rat to injury.
The response of the thoracic aorta to balloon-catheter-induced endothelial denudation was studied in two animal models of diabetes: the obese Zucker rat and the streptozotocin-treated Wistar rat. The obese Zucker rat, an animal with a metabolic profile similar to that of noninsulin-dependent human diabetics, was characterized by excessive body weight, hyperinsulinemia, hyperlipidemia, and a mil...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2000
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2000.00042.x